Description

Thioridazine-5-Sulfoxide is a key pharmaceutical intermediate and metabolite of the antipsychotic drug thioridazine. This compound is of significant importance for research and development in neuropharmacology and for the quality control of related pharmaceutical products. It is primarily required by pharmaceutical manufacturers, analytical laboratories, and research institutions engaged in drug metabolism studies, impurity profiling, and reference standard preparation.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis and research of phenothiazine-derived antipsychotic agents.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical testing.
• Metabolite Studies: Essential for in-vitro and in-vivo drug metabolism and pharmacokinetics (DMPK) research related to thioridazine.
• Impurity Profiling: Serves as a specified impurity standard to monitor and control the quality of thioridazine active pharmaceutical ingredient (API) and finished dosage forms.
• Biochemical Research: Utilized in neuroscience research to study the mechanisms of action and side-effect profiles of phenothiazine drugs.

Basic Information

Product Name	Thioridazine-5-Sulfoxide
CAS No.	7776-05-8
Molecular Formula	C21H26N2OS2
Molecular Weight	386.57 g/mol
Synonyms	Thioridazine Sulfoxide; Thioridazine 5-Sulfoxide; 10-[2-(1-Methyl-2-piperidyl)ethyl]-2-(methylthio)-10H-phenothiazine 5-oxide; 2-Methylmercapto-10-[2-(1-methyl-2-piperidyl)ethyl]phenothiazine-5-oxide; Thioridazine S-Oxide; Thioridazine Metabolite; SQ 4918; SQ-4918
EINECS	Contact for details

Quality Control

Our Thioridazine-5-Sulfoxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assay by HPLC, and control of related substances. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to ensure traceability and compliance with your research or quality specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.