Description

Z-Gln-Onp CAS NO 7763-16-8 is a protected glutamine derivative, specifically N-benzyloxycarbonyl-L-glutamine p-nitrophenyl ester, widely used as a key building block in peptide synthesis. This compound is critical for researchers and manufacturers requiring high-purity, reactive intermediates to construct complex peptides with precision. It is primarily utilized by the pharmaceutical, biotechnology, and academic research sectors for developing therapeutic peptides, biochemical probes, and novel biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a crucial activated ester for the efficient incorporation of glutamine residues into peptide chains.
• Solution-Phase Peptide Coupling: Used as a reactive intermediate in classical solution-phase methodologies for constructing specific peptide bonds.
• Pharmaceutical Intermediate: A key raw material in the research and development of peptide-based active pharmaceutical ingredients (APIs).
• Bioconjugation: Facilitates the site-specific labeling or modification of proteins and other biomolecules.
• Biochemical Research: Employed in studies of enzyme substrates, receptor ligands, and other bioactive peptide sequences.
• Custom Peptide Production: Essential for contract research and manufacturing organizations (CROs/CMOs) producing bespoke peptides for clients.

Basic Information

Product Name	Z-Gln-Onp
CAS No.	7763-16-8
Molecular Formula	C19H19N3O7
Molecular Weight	401.37 g/mol
Synonyms	N-Carbobenzoxy-L-glutamine p-nitrophenyl ester; Z-L-Glutamine p-nitrophenyl ester; Nα-Cbz-L-glutamine 4-nitrophenyl ester; N-Benzyloxycarbonyl-L-glutamine 4-nitrophenyl ester; (S)-2-(((Benzyloxy)carbonyl)amino)-5-((4-nitrophenoxy)carbonyl)pentanoic acid; Z-Gln-ONp; Cbz-Gln-ONp
EINECS	231-835-2

Quality Control

Our Z-Gln-Onp is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]D20	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.