Description

Boc-Ser(Tbu)-Oh CAS NO 7738-22-9 is a protected amino acid derivative, specifically N-tert-Butoxycarbonyl-O-tert-butyl-L-serine, serving as a critical building block in solid-phase peptide synthesis (SPPS). Its primary value lies in providing orthogonal protection for both the amine and side-chain hydroxyl groups of serine, enabling precise and sequential peptide chain assembly. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing therapeutic peptides, diagnostic agents, and complex biomolecules.

Application

• Pharmaceutical Peptide Synthesis: A key raw material for the controlled incorporation of serine residues into novel peptide-based drug candidates, including hormones, antibiotics, and enzyme inhibitors.
• Bioconjugation and Linker Chemistry: Used to introduce functionalized serine moieties into proteins, antibodies, or other biomolecules for drug delivery systems and diagnostic probes.
• Combinatorial Chemistry Libraries: Employed in the automated synthesis of diverse peptide libraries for high-throughput screening in drug discovery.
• Research & Development: Serves as a standard reagent in academic and industrial R&D labs for studying peptide structure-activity relationships (SAR) and developing new synthetic methodologies.
• Production of Complex Peptide Fragments: Integral for the synthesis of challenging peptide sequences where side-chain protection is required to prevent side reactions during coupling.

Basic Information

Product Name	Boc-Ser(Tbu)-Oh
CAS No.	7738-22-9
Molecular Formula	C₁₂H₂₃NO₅
Molecular Weight	261.32 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-O-tert-butyl-L-serine; Boc-Ser(OtBu)-OH; Boc-L-serine(O-tert-butyl) ether; (2S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-[(2-methylpropan-2-yl)oxy]propanoic acid; N-Boc-O-t-butyl-L-serine; tert-Butyl N-[(1S)-1-(tert-butoxymethyl)-2-carboxyethyl]carbamate; Boc-Ser(TBU)-OH; L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-, 1-(1,1-dimethylethyl) ester
EINECS	Contact for details

Quality Control

Our Boc-Ser(Tbu)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for chiral purity and assay, and is supplied with a detailed Certificate of Analysis (COA). We adhere to cGMP guidelines where applicable to support our customers' regulatory requirements in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation [α]²⁰D	-15.0° to -18.0° (c=1 in AcOH)
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.