Description

(8S)-4-o-Methyltetrodotoxin is a potent, naturally occurring neurotoxin and a key methylated derivative of tetrodotoxin (TTX). This compound is of significant interest in advanced biochemical and pharmacological research due to its specific and high-affinity blockade of voltage-gated sodium channels. It serves as an essential reference standard and research tool for neuroscientists, toxicologists, and pharmaceutical developers working on ion channel physiology, analgesic drug discovery, and marine toxin analysis.

Application

• Neuroscience Research: Critical tool for studying the function and pharmacology of voltage-gated sodium channels (Nav channels) in neuronal signaling.
• Analytical Reference Standard: Used as a certified reference material (CRM) in the identification and quantification of tetrodotoxin analogs in food safety and environmental monitoring.
• Pharmacological Studies: Employed in the development and screening of novel analgesic compounds and local anesthetics that target sodium channels.
• Toxicology & Biosafety: Essential for research into the mechanisms of tetrodotoxin poisoning and the development of detection methods and potential antidotes.
• Biochemical Assays: Used in competitive binding assays and receptor studies to understand toxin-receptor interactions.
• Marine & Environmental Science: Applied in research on the biosynthesis of toxins in pufferfish, bacteria, and other marine organisms.

Basic Information

Product Name	(8S)-4-o-Methyltetrodotoxin
CAS No.	7724-39-2
Molecular Formula	C11H17N3O8
Molecular Weight	319.27 g/mol
Synonyms	4-O-Methyltetrodotoxin; 4-O-Methyl-TTX; 4-Methoxy-tetrodotoxin; Tetrodotoxin 4-methyl ether; Anhydrotetrodotoxin 4-O-methyl ether; 4-Desoxy-4-methoxytetrodotoxin
EINECS	Contact for details

Quality Control

Our (8S)-4-o-Methyltetrodotoxin is produced and handled under strict quality management protocols to ensure the highest standards of purity and identity for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profile. We adhere to relevant guidelines for reference standards to ensure batch-to-batch consistency and reliability for your critical research.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. The product should be kept in a cool, dry place and allowed to reach room temperature before opening to prevent condensation. Handle with appropriate personal protective equipment in a well-ventilated laboratory setting.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.