Description

n-(o-Nitrophenylthio)-L-Isoleucine is a specialized chiral amino acid derivative featuring a nitrophenylthio protecting group. This compound is of significant value in advanced organic synthesis and pharmaceutical research, particularly for the preparation of complex peptides and bioactive molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for applications requiring high-purity, custom amino acid building blocks.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel peptide-based drugs and therapeutic agents.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected L-isoleucine derivative.
• Bioconjugation Chemistry: The reactive thioether and nitro groups facilitate its use in linker chemistry and bioconjugation strategies.
• Proteomics Research: Employed in the study of protein structure, function, and enzyme-substrate interactions.
• Chemical Biology Tool: Serves as a precursor for designing activity-based probes and inhibitors targeting specific enzymes.
• Fine Chemical Synthesis: A versatile intermediate for synthesizing complex organic molecules with specific stereochemical requirements.

Basic Information

Product Name	n-(o-Nitrophenylthio)-L-Isoleucine
CAS No.	7690-79-1
Molecular Formula	C16H22N2O4S
Molecular Weight	338.42 g/mol
Synonyms	L-Isoleucine, N-[(2-nitrophenyl)thio]-; N-(2-Nitrophenylthio)-L-isoleucine; N-(o-Nitrophenylthio)-L-isoleucine; (2S,3S)-2-[[(2-Nitrophenyl)sulfanyl]amino]-3-methylpentanoic acid; o-Nitrophenylthio-L-isoleucine; 2-[[(2-Nitrophenyl)thio]amino]-3-methylpentanoic acid; N-(2-Nitrobenzenethiol)-L-isoleucine
EINECS	Contact for details

Quality Control

Our n-(o-Nitrophenylthio)-L-Isoleucine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the exacting standards required for research and synthesis. A Certificate of Analysis (COA) detailing purity, identity, and specific test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown powder or crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.