Description

Proline, 4-Fluoro-5-Oxo- (7Ci,8Ci,9Ci) CAS NO 7682-57-7 is a fluorinated derivative of the amino acid proline, serving as a high-value pharmaceutical intermediate and building block for advanced organic synthesis. Its unique structure, incorporating both a fluorine atom and a ketone group, makes it a critical precursor for developing novel active pharmaceutical ingredients (APIs) and fine chemicals. This compound is essential for research and production in pharmaceutical, agrochemical, and biochemical sectors, where precise molecular modification is required.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly protease inhibitors and other targeted therapies.
• Peptidomimetics Research: Used in medicinal chemistry to create modified peptide analogs with enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a precursor for developing novel fluorinated pesticides and herbicides with improved efficacy.
• Biochemical Probe Development: Utilized in life science research to study enzyme mechanisms and protein interactions where proline modification is relevant.
• Organofluorine Chemistry: A valuable substrate for exploring new fluorination reactions and creating fluorine-containing compound libraries.
• Chiral Auxiliary/Synthon: Its inherent chirality makes it useful in asymmetric synthesis for constructing complex molecules with defined stereochemistry.

Basic Information

Product Name	Proline, 4-Fluoro-5-Oxo- (7Ci,8Ci,9Ci)
CAS No.	7682-57-7
Molecular Formula	C5H6FNO3
Molecular Weight	147.10 g/mol
Synonyms	4-Fluoro-5-oxoproline; (4R)-4-Fluoro-5-oxo-L-proline; 4-Fluoro-5-oxo-L-proline; 5-Oxo-4-fluoroproline; 4-Fluoropyroglutamic Acid; 4-Fluoro-5-oxopyrrolidine-2-carboxylic acid; L-4-Fluoro-5-oxoproline; 7682-57-7
EINECS	Contact for details

Quality Control

Our Proline, 4-Fluoro-5-Oxo- is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to confirm stereochemical integrity, ensuring it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, and we support compliance with cGMP and ISO guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.