Description

Trimethylsilyl Cyanide is a versatile organosilicon reagent primarily used as a cyano source and a silylating agent in organic synthesis. Its high reactivity and ability to introduce both cyano and trimethylsilyl groups make it a critical building block for constructing complex molecular architectures. This compound is essential for research and production in the pharmaceutical, agrochemical, and advanced materials sectors, where it facilitates the synthesis of nitriles, cyanohydrins, and various heterocyclic compounds.

Application

• Pharmaceutical Intermediates: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing cyano groups and protecting alcohols.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides that contain nitrile functionalities.
• Cyanohydrin Formation: Employed in the trimethylsilyl cyanide (TMSCN)-mediated addition to carbonyl compounds (aldehydes and ketones) to form cyanohydrin trimethylsilyl ethers, valuable chiral intermediates.
• Nitrile Synthesis: Facilitates the conversion of alkyl halides, epoxides, and other electrophiles into their corresponding nitriles.
• Silyl Protecting Agent: Protects hydroxyl groups in multi-step synthetic sequences due to its silylating properties.
• Material Science Research: Serves as a precursor in the development of silicon-based polymers and advanced ceramic materials.

Basic Information

Item	Detail
Product Name	Trimethylsilyl Cyanide
CAS No.	7677-24-9
Molecular Formula	C4H9NSi
Molecular Weight	99.21 g/mol
Synonyms	Trimethylsilyl Cyanide; Cyanotrimethylsilane; TMSCN; Trimethylsilanecarbonitrile; (Cyanomethyl)trimethylsilane; NSC 93766; Silane, cyanotrimethyl-; Trimethylcyanidosilane
EINECS	231-650-5

Quality Control

Our Trimethylsilyl Cyanide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including assay by GC, purity verification, and impurity profiling, to ensure it meets the high standards required for synthetic applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its highly volatile nature, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) to maintain purity and prevent moisture ingress. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.