Description

Methotrimeprazine Sulfoxide is a key pharmaceutical intermediate and metabolite of the phenothiazine derivative methotrimeprazine. This compound is of significant importance for research and development in neuropharmacology and analytical chemistry. It is primarily required by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories for use in drug metabolism studies, impurity profiling, and as a reference standard.

Application

• Pharmaceutical Reference Standard: Used for the identification, assay, and impurity testing of methotrimeprazine in quality control laboratories.
• Metabolite Research: Critical for in-vitro and in-vivo drug metabolism and pharmacokinetic (DMPK) studies to understand the biotransformation pathways of methotrimeprazine.
• Analytical Method Development: Serves as a critical component in developing and validating HPLC, LC-MS, and GC-MS methods for phenothiazine-class compounds.
• Impurity Synthesis and Profiling: Used to synthesize and qualify specified impurities and degradation products for regulatory filings (e.g., ICH guidelines).
• Pharmacological Research: Employed in preclinical studies to investigate the activity and safety profile of methotrimeprazine metabolites.
• Chemical Intermediate: Potential use in the synthetic pathway for developing novel phenothiazine derivatives or related therapeutic agents.

Basic Information

Product Name	Methotrimeprazine Sulfoxide
CAS No.	7606-29-3
Molecular Formula	C19H24N2O2S
Molecular Weight	344.47 g/mol
Synonyms	Levomepromazine Sulfoxide; Methotrimeprazine S-Oxide; 2-Methoxy-10-(2-methyl-3-dimethylaminopropyl)phenothiazine 5-Oxide; 5-Oxide of Methotrimeprazine; Levomepromazine Sulfoxide; Nozinan Sulfoxide; 7606-29-3; Methotrimeprazine Sulphoxide
EINECS	Contact for details

Quality Control

Our Methotrimeprazine Sulfoxide is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assay by HPLC, and control of related substances. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and pharmaceutical intermediate standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.