Description

Methyl 3,3,3-Trifluoro-2-Hydroxy-2-Trifluoromethylpropionate is a high-value fluorinated building block characterized by its unique gem-diol ester structure. This compound is essential for introducing the highly stable and lipophilic trifluoromethyl group into complex molecules, significantly altering their physical and biological properties. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of advanced intermediates, active ingredients, and novel materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antiviral compounds.
• Agrochemical Synthesis: Used to create advanced fluorinated herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances bioavailability and environmental stability.
• Advanced Material Development: Serves as a monomer or modifier in the production of specialty polymers, coatings, and liquid crystals with enhanced chemical resistance, thermal stability, and optical properties.
• Organic Synthesis Building Block: Employed in asymmetric synthesis and catalysis research to construct complex, stereodefined molecules for medicinal chemistry and material science applications.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring new methodologies for C-F bond formation and the development of novel fluorinated compounds.

Basic Information

Product Name	Methyl 3,3,3-Trifluoro-2-Hydroxy-2-Trifluoromethylpropionate
CAS No.	7594-51-6
Molecular Formula	C6H4F6O3
Molecular Weight	238.09 g/mol
Synonyms	Methyl 2-Hydroxy-3,3,3-trifluoro-2-(trifluoromethyl)propionate; 3,3,3-Trifluoro-2-hydroxy-2-trifluoromethylpropionic Acid Methyl Ester; Hexafluoroisopropylidene Malonic Acid Monomethyl Ester; Methyl 2-Hydroxyhexafluoroisobutyrate; Methyl α-Hydroxyhexafluoroisobutyrate; HFIB Methyl Ester; 2-Hydroxyhexafluoroisobutyric Acid Methyl Ester; Methyl Ester of Hexafluoroisopropylidene Malonic Acid
EINECS	Contact for details

Quality Control

Our production of Methyl 3,3,3-Trifluoro-2-Hydroxy-2-Trifluoromethylpropionate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.