Description

1,1-Bis(Trifluoromethyl)-2,2,2-Trichloroethanol is a specialized fluorinated and chlorinated organic compound that serves as a versatile building block in advanced chemical synthesis. Its unique structure, featuring both trifluoromethyl and trichloromethyl groups, makes it a valuable precursor for introducing fluorinated motifs into target molecules, which is critical for modifying physical and chemical properties. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality fluorination reagents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly those requiring fluorinated structures to enhance metabolic stability, bioavailability, and membrane permeability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the introduction of fluorine atoms can significantly increase biological activity and environmental persistence.
• Fluorinated Polymer & Material Science: Serves as a monomer or modifier in the synthesis of specialty polymers, coatings, and electronic materials to impart unique properties like chemical resistance, low surface energy, and thermal stability.
• Organic Synthesis & Catalysis: Employed as a reagent in nucleophilic trifluoromethylation reactions and as a precursor for generating ligands or catalysts used in asymmetric synthesis and cross-coupling reactions.
• Liquid Crystal & OLED Material Research: Acts as a building block for creating fluorinated components in liquid crystal mixtures and organic light-emitting diode (OLED) materials to improve performance characteristics.

Basic Information

Product Name	1,1-Bis(Trifluoromethyl)-2,2,2-Trichloroethanol
CAS No.	7594-49-2
Molecular Formula	C4HCl3F6O
Molecular Weight	267.40 g/mol
Synonyms	2,2,2-Trichloro-1,1-bis(trifluoromethyl)ethanol; 1,1-Bis(trifluoromethyl)-2,2,2-trichloroethanol; 2,2,2-Trichloro-1,1-bis(trifluoromethyl)ethan-1-ol; Hexafluoro-2-propanol, 2,2,2-trichloro-; α,α-Bis(trifluoromethyl)-α-trichloromethylcarbinol; (Trifluoromethyl)trichloromethylcarbinol (as a common name derivative); TCTFE (abbreviation based on structure); Perfluoro-tert-butyl alcohol trichloro derivative
EINECS	Contact for details

Quality Control

Our 1,1-Bis(Trifluoromethyl)-2,2,2-Trichloroethanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography and spectroscopy, to ensure high purity and consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to the presence of halogenated groups, ensure the container is kept upright to prevent leakage and is clearly labeled.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.