Description

n-3-5-Dinitrobenzoyl-L-Leucine is a high-purity chiral derivatizing agent and synthetic intermediate. This compound is critical for the resolution and analysis of enantiomers, particularly in pharmaceutical research and development. It is primarily utilized by analytical laboratories, R&D chemists, and manufacturers in the pharmaceutical and fine chemical industries for ensuring chiral purity and developing stereospecific synthesis pathways.

Application

• Chiral Derivatizing Agent: Used for the resolution of racemic mixtures via formation of diastereomeric derivatives for analytical separation by HPLC or GC.
• Pharmaceutical Intermediate: Serves as a key building block in the stereoselective synthesis of active pharmaceutical ingredients (APIs) and peptide analogs.
• Analytical Standard: Employed as a reference standard in method development and validation for chiral analysis in quality control laboratories.
• Biochemical Research: Used in studies of enzyme kinetics and receptor-ligand interactions where stereochemical integrity is paramount.
• Asymmetric Synthesis: Acts as a precursor or auxiliary in catalytic asymmetric reactions to induce chirality in target molecules.
• Peptide Chemistry: Utilized for the introduction of protected leucine derivatives or as a model compound in peptide coupling studies.

Basic Information

Product Name	n-3-5-Dinitrobenzoyl-L-Leucine
CAS No.	7495-01-4
Molecular Formula	C13H15N3O7
Molecular Weight	325.28 g/mol
Synonyms	N-(3,5-Dinitrobenzoyl)-L-leucine; (S)-2-(3,5-Dinitrobenzamido)-4-methylpentanoic acid; L-Leucine, N-(3,5-dinitrobenzoyl)-; DNBL; 3,5-DNB-Leucine; Dinitrobenzoyl leucine; Chiral derivatization reagent for leucine
EINECS	Contact for details

Quality Control

Our n-3-5-Dinitrobenzoyl-L-Leucine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent specifications for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-Isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.