Description

Zalcitabine Related Compound A (2',3'-Didehydro-2',3'-Dideoxycytidine) is a high-purity chemical reference standard essential for pharmaceutical research and quality control. This compound, supplied in a convenient 50 mg quantity, serves as a critical impurity marker and analytical standard for the antiretroviral drug Zalcitabine (ddC). It is primarily utilized by pharmaceutical manufacturers, analytical laboratories, and research institutions engaged in the development, validation, and quality assurance of nucleoside reverse transcriptase inhibitors (NRTIs).

Application

• Pharmaceutical Impurity Profiling: Used as a certified reference material for the identification and quantification of related substances in Zalcitabine (ddC) Active Pharmaceutical Ingredients (APIs) and finished drug products.
• Analytical Method Development & Validation: A critical component for developing and validating HPLC, UPLC, or LC-MS methods to ensure specificity, accuracy, and precision in impurity analysis.
• Quality Control & Assurance (QC/QA): Serves as a system suitability standard and for routine batch testing in GMP-compliant pharmaceutical manufacturing environments.
• Stability Studies: Employed to monitor degradation pathways and establish impurity limits during forced degradation and long-term stability testing of Zalcitabine formulations.
• Regulatory Compliance & Documentation: Supports regulatory filings (e.g., for FDA, EMA) by providing definitive characterization data for specified impurities as per ICH guidelines.
• Biochemical Research: Used in studies investigating the structure-activity relationships, metabolism, and resistance mechanisms of dideoxynucleoside analogs.

Basic Information

Product Name	Zalcitabine Related Compound A (2',3'-Didehydro-2',3'-Dideoxycytidine)
CAS No.	7481-88-1
Molecular Formula	C9H11N3O3
Molecular Weight	209.20 g/mol
Synonyms	2',3'-Didehydro-2',3'-Dideoxycytidine; D4C; 2',3'-Dideoxy-2',3'-didehydrocytidine; Zalcitabine Impurity A; ddC Related Compound A; 1-((2R,5S)-5-(Hydroxymethyl)-2,5-dihydrofuran-2-yl)-1,2-dihydropyrimidine-2,4-dione; Cytidine, 2',3'-didehydro-2',3'-dideoxy-
EINECS	Contact for details

Quality Control

Every batch of Zalcitabine Related Compound A is manufactured and analyzed under strict quality management systems. Our products undergo rigorous identity, purity, and impurity profile testing using advanced analytical techniques (HPLC, NMR, MS) to ensure compliance with pharmacopeial standards. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided to support your regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation due to moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.