Description

n-Cbz-L-Tryptophan CAS NO 7432-21-5 is a protected derivative of the essential amino acid L-tryptophan, featuring a carboxybenzyl (Cbz) group on the amine functionality. This compound is a critical building block in peptide synthesis, offering orthogonal protection strategies essential for complex, multi-step organic and medicinal chemistry. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutic peptides and conducting biochemical research.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of tryptophan residues into peptide chains, preventing unwanted side reactions during synthesis.
• Solution-Phase Peptide Chemistry: Used in traditional coupling reactions for the production of custom peptides and peptide mimetics in research and development.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of peptide-based active pharmaceutical ingredients (APIs) and investigational new drugs.
• Bioconjugation and Probe Development: Facilitates the site-specific labeling and modification of peptides and proteins for diagnostic and research applications.
• Academic and Industrial R&D: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and the discovery of new bioactive compounds.
• Production of Protected Peptide Fragments: Used to generate specific peptide sequences for fragment condensation strategies in large-scale peptide manufacturing.

Basic Information

Product Name	n-Cbz-L-Tryptophan
CAS No.	7432-21-5
Molecular Formula	C20H20N2O4
Molecular Weight	352.39 g/mol
Synonyms	Nα-Carbobenzoxy-L-tryptophan; N-Carbobenzyloxy-L-tryptophan; Z-L-Tryptophan; Z-Trp-OH; (S)-2-(((Benzyloxy)carbonyl)amino)-3-(1H-indol-3-yl)propanoic acid; CBZ-L-Tryptophan; L-Tryptophan, N-[(phenylmethoxy)carbonyl]-; N-Benzyloxycarbonyl-L-tryptophan
EINECS	231-084-7

Quality Control

Our n-Cbz-L-Tryptophan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and cGMP-grade requirements for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Specific Rotation [α]20/D	-15.0° to -18.0° (c=1 in DMF)
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%
Chiral Purity (HPLC)	≥99.0% (L-isomer)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.