Description

Neopentyllithium is a highly reactive organolithium compound, specifically a tertiary alkyllithium reagent. Its sterically hindered neopentyl structure makes it a powerful, non-nucleophilic strong base and a key initiator for anionic polymerization processes. This compound is essential for synthetic chemists and process engineers in advanced materials and pharmaceutical development. It is primarily utilized in the production of specialized polymers and as a critical reagent for deprotonation and metal-halogen exchange reactions in fine chemical synthesis.

Application

• Anionic Polymerization Initiator: A fundamental component for synthesizing block copolymers, thermoplastic elastomers, and polymers with controlled molecular weight and narrow polydispersity.
• Organic Synthesis Reagent: Employed as a strong, sterically hindered base for regioselective deprotonation of sensitive substrates and for efficient lithium-halogen exchange reactions.
• Pharmaceutical Intermediate Synthesis: Used in the construction of complex molecular architectures for active pharmaceutical ingredients (APIs) and advanced intermediates.
• Specialty Polymer Production: Critical in manufacturing high-performance materials such as solution-polymerized styrene-butadiene rubber (S-SBR) and other tailored polymers for the automotive and specialty plastics industries.
• Catalyst and Ligand Precursor: Serves as a starting material for generating other organometallic catalysts and ligands used in asymmetric synthesis and catalysis.
• Research & Development: A valuable tool in academic and industrial R&D labs for exploring new polymerization methodologies and synthetic pathways.

Basic Information

Product Name	Neopentyllithium
CAS No.	7412-67-1
Molecular Formula	C5H11Li
Molecular Weight	78.04 g/mol
Synonyms	Lithium neopentyl; Neopentyl lithium; 2,2-Dimethylpropyl lithium; (2,2-Dimethylpropyl)lithium; tert-Butylmethyllithium; Lithium(1+) 2,2-dimethylpropylide; Lithium 2,2-dimethylpropylide
EINECS	Contact for details

Quality Control

Our Neopentyllithium is manufactured under stringent quality control protocols to ensure batch-to-batch consistency and high reactivity. Production adheres to cGMP guidelines where applicable, and each lot is accompanied by a comprehensive Certificate of Analysis (COA). The COA provides detailed results for key parameters including assay (by titration), solvent content, and the absence of protic impurities. We are committed to supplying material that meets the exacting standards required for polymerization and sensitive synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile and pyrophoric nature, this material must be stored under a dry, inert atmosphere (argon or nitrogen) at temperatures between 2°C and 8°C. The storage area must be cool, well-ventilated, and free from ignition sources. Keep away from moisture, air, and strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (IR)	Conforms
Assay (Titration)	≥ 0.8 M in specified solvent (e.g., cyclohexane)
Solvent	As specified (e.g., Cyclohexane, Heptane)
Acidity (as HCl)	≤ 1.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.