Description

D-Erythro-Chloramphenicol CAS NO 7387-98-6 is the biologically active stereoisomer of the broad-spectrum antibiotic chloramphenicol. This high-purity compound is critical for research and development in pharmaceutical chemistry and microbiology. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for analytical standards, reference materials, and as a key intermediate in specialized synthesis.

Application

• Pharmaceutical Reference Standard: Serves as a certified primary standard for quality control and assay validation of chloramphenicol-based pharmaceutical products.
• Microbiological Research: Used in laboratory studies to investigate bacterial protein synthesis inhibition, antibiotic resistance mechanisms, and structure-activity relationships.
• Analytical Chemistry: Employed as a high-purity calibrant and internal standard in chromatographic (HPLC, LC-MS) methods for accurate quantification.
• Biochemical Reagent: Acts as a selective agent in cell culture media and in molecular biology experiments to study gene expression and protein production.
• API Intermediate: Functions as a critical starting material or intermediate in the synthesis of specialized chloramphenicol derivatives and novel antibiotic compounds.

Basic Information

Product Name	D-Erythro-Chloramphenicol
CAS No.	7387-98-6
Molecular Formula	C11H12Cl2N2O5
Molecular Weight	323.13 g/mol
Synonyms	(-)-Chloramphenicol; D-(-)-Chloramphenicol; D-(-)-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-p-nitrophenethyl]acetamide; (1R,2R)-2,2-Dichloro-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide; Chloramphenicol D-(-)-threo isomer; Antibiotic from *Streptomyces venezuelae* (D-form); Levomycetin (D-form)
EINECS	230-986-0

Quality Control

Our D-Erythro-Chloramphenicol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification (IR, HPLC), assay (HPLC), and impurity profiling, to ensure it meets high-purity standards suitable for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to yellowish-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Specific Rotation [α]20/D	-18.5° to -21.5° (c=5 in ethanol)
Water (Karl Fischer)	≤1.0%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.