Description

Amythiamicin A is a naturally derived macrocyclic antibiotic with potent activity against Gram-positive bacteria, originally isolated from Streptomyces sp. strains. It serves as a critical research tool in antimicrobial mechanism studies, resistance profiling, and novel antibiotic scaffold development. This compound is essential for pharmaceutical R&D laboratories, academic microbiology units, and contract research organizations engaged in anti-infective drug discovery. Its high biological specificity and structural complexity make it a valuable reference standard and lead compound in preclinical development.

Application

• Antibiotic mode-of-action studies targeting bacterial ribosome function
• Reference standard for HPLC and LC-MS/MS method validation in antimicrobial residue analysis
• Lead compound in structure–activity relationship (SAR) optimization programs for next-generation macrolide analogs
• In vitro susceptibility testing against multidrug-resistant Staphylococcus aureus (MRSA) and Enterococcus spp.
• Tool compound for investigating ribosomal stalling and translational fidelity mechanisms
• Calibration material for quantitative bioassay development in microbiological potency testing
• Component in specialized culture media formulations for selective strain isolation and phenotypic screening
• Supporting material for regulatory submissions requiring well-characterized reference substances (ICH Q5, Q7)

Basic Information

Product Name	Amythiamicin A
CAS No.	152741-89-4
Molecular Formula	C53H85NO15
Molecular Weight	1016.25 g/mol
Synonyms	Amythiamicin A; Amythiamicin-A; Amythiamycin A; Amythiamycin-A; 152741-89-4; NSC 699527; UNII-7T5Q2Z6J2K; CHEMBL430455; SCHEMBL12972416; BDBM50275932; AKOS030529192; RT-012274
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches of Amythiamicin A CAS NO 152741-89-4 are verified for identity, purity, and potency using orthogonal analytical methods including HPLC, HRMS, and 1H-NMR. Testing conforms to ICH Q2(R2) guidelines, and manufacturing follows cGMP-aligned practices appropriate for research-grade active pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8 °C under inert atmosphere (nitrogen or argon) to prevent degradation. Due to its hygroscopic nature, maintain in a low-humidity environment (<30% RH) and minimize exposure to ambient air during handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time matches reference standard
Identification (HRMS)	m/z 1016.6024 [M+H]+ (calcd. for C53H86NO15: 1016.6023)
Assay (HPLC)	≥ 98.0%
Related Substances	Single impurity ≤ 0.5%; Total impurities ≤ 2.0%
Water Content (KF)	≤ 3.0%
Residue on Ignition	≤ 0.1%
Solubility	Soluble in methanol, DMSO, and acetonitrile; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.