Description

L-(+)-Threo-Chloramphenicol is the biologically active stereoisomer of the broad-spectrum antibiotic chloramphenicol. This compound is critical for its potent bacteriostatic activity, primarily by inhibiting bacterial protein synthesis. It is an essential raw material for the pharmaceutical industry, particularly in the formulation of specific ophthalmic solutions and topical preparations where targeted antimicrobial action is required.

Application

• Active Pharmaceutical Ingredient (API) in antibiotic formulations.
• Key intermediate in the synthesis of advanced pharmaceutical compounds.
• Research and development of novel antimicrobial agents.
• Manufacturing of veterinary medicinal products.
• Component in microbiological culture media for selective growth inhibition.
• Reference standard for analytical and quality control laboratories.

Basic Information

Product Name	L-(+)-Threo-Chloramphenicol
CAS No.	134-90-7
Molecular Formula	C11H12Cl2N2O5
Molecular Weight	323.13 g/mol
Synonyms	Chloramphenicol (L-threo isomer); (-)-D-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-p-nitrophenethyl]acetamide; Chloromycetin; L-threo-(-)-2,2-Dichloro-N-[1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide; Antibiotic from *Streptomyces venezuelae*; D-(-)-threo-Chloramphenicol; Levomycetin
EINECS	205-161-1

Quality Control

Our L-(+)-Threo-Chloramphenicol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. A detailed Certificate of Analysis (COA) confirming identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to yellowish-white crystalline powder
Identification (IR)	Conforms to standard
Assay (HPLC)	≥ 98.0%
Specific Rotation [α]D20	+18.5° to +21.5°
Melting Point	149°C - 153°C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.