Description

Thiamphenicol CAS NO 15318-45-3 is a synthetic broad-spectrum antibiotic belonging to the amphenicol class, structurally related to chloramphenicol. It is valued for its potent bacteriostatic activity against a wide range of Gram-positive and Gram-negative bacteria, with a more favorable safety profile regarding the risk of aplastic anemia. This compound is essential for manufacturers in the pharmaceutical and veterinary sectors requiring a reliable, high-purity active pharmaceutical ingredient (API) for therapeutic formulations.

Application

• Pharmaceutical API: Primary use as an active ingredient in human and veterinary antibiotic preparations.
• Veterinary Medicine: Formulated into injectables, oral solutions, and premixes for treating bacterial infections in livestock, poultry, and aquaculture.
• Aquaculture: Used in medicated feeds to control bacterial diseases in farmed fish and shrimp.
• Research & Development: Serves as a critical reference standard and intermediate in microbiological and pharmacological research.
• Topical Formulations: Incorporated into ointments, creams, and eye/ear drops for localized bacterial infections.

Basic Information

Product Name	Thiamphenicol
CAS No.	15318-45-3
Molecular Formula	C12H15Cl2NO5S
Molecular Weight	356.22 g/mol
Synonyms	D-Threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-p-(methylsulfonyl)phenethyl]acetamide; Dextrosulphenidol; Thiamphenicolum; Urfamycin; Thiophenicol; Tiamfenicol; Antibiotic U-21,963; NSC-106568; Win-5063-2
EINECS	239-357-4

Quality Control

Our Thiamphenicol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical use, including identity, potency, and impurity profile verification. A Certificate of Analysis (COA) detailing specific results for assay, related substances, residual solvents, and microbiological quality is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. The product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%
Heavy Metals	≤ 20 ppm
Microbial Limits	Meets Ph. Eur./USP requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.