Description

Z-D-Phe-Nh2 is a protected amino acid derivative, specifically the benzyloxycarbonyl (Z or Cbz) protected form of D-phenylalanine amide. This compound serves as a crucial chiral building block in the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), diagnostic agents, and specialized biochemical tools.

Application

• Pharmaceutical Intermediates: Key chiral synthon in the synthesis of peptide-based drugs and protease inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce D-phenylalanine residues with orthogonal protection.
• Biochemical Research: Serves as a standard or reagent in enzymatic studies and for investigating peptide structure-activity relationships (SAR).
• Asymmetric Synthesis: Employed as a starting material or auxiliary in the preparation of non-natural amino acids and chiral catalysts.
• Diagnostic Development: Can be incorporated into substrates for diagnostic assays and medical imaging probes.

Basic Information

Product Name	Z-D-Phe-Nh2
CAS No.	7376-90-1
Molecular Formula	C17H18N2O3
Molecular Weight	298.34 g/mol
Synonyms	N-[(Benzyloxy)carbonyl]-D-phenylalaninamide; Cbz-D-Phe-NH2; Z-D-Phenylalanine amide; (R)-2-((((Benzyloxy)carbonyl)amino)-3-phenylpropanamide; N-Carbobenzoxy-D-phenylalanine amide; D-Phenylalanine, N-[(phenylmethoxy)carbonyl]-, amide; Z-D-Phenylalaninamide
EINECS	Contact for details

Quality Control

Our Z-D-Phe-Nh2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, specific rotation, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Specific Rotation	Contact for details
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.