Description

3-Chlorotyrosine is a halogenated derivative of the amino acid tyrosine, characterized by the substitution of a chlorine atom at the 3-position of the aromatic ring. This modification makes it a valuable biochemical marker for oxidative stress and a critical intermediate in the synthesis of more complex bioactive molecules. It is essential for researchers and manufacturers in the pharmaceutical, diagnostic, and life science sectors who require high-purity, well-characterized building blocks for advanced applications.

Application

• Biomarker Research: Used as a specific marker for chlorination activity, particularly in studying inflammation, atherosclerosis, and other diseases involving myeloperoxidase-driven oxidative stress.
• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the development of novel drug candidates and active pharmaceutical ingredients (APIs).
• Diagnostic Reagent Development: Employed in the formulation of assay kits and standards for the detection and quantification of protein oxidation in clinical and research settings.
• Biochemical Research: Utilized in enzymatic studies, metabolic pathway analysis, and as a substrate or inhibitor in various biochemical assays.
• Reference Standard: Acts as a high-purity analytical standard for chromatography (HPLC, LC-MS) to ensure accuracy in quantitative analysis.
• Peptide Synthesis: Incorporated into custom peptides to study structure-activity relationships or to create chlorinated peptide analogs for biological evaluation.

Basic Information

Product Name	3-Chlorotyrosine
CAS No.	7298-90-0
Molecular Formula	C9H10ClNO3
Molecular Weight	215.63 g/mol
Synonyms	3-Chloro-L-tyrosine; L-3-Chlorotyrosine; (2S)-2-Amino-3-(3-chloro-4-hydroxyphenyl)propanoic acid; 3-Chloro-4-hydroxyphenylalanine; 3-Cl-Tyr; 3CT; 3-Chlorotyrosine, Free Acid; Tyrosine, 3-chloro-
EINECS	Contact for details

Quality Control

Our 3-Chlorotyrosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, MS). We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and development grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.