Description

1-Dimethylamino-2-Propyne is a versatile tertiary amine alkyne building block, characterized by its reactive terminal alkyne and dimethylamino functional groups. This compound is valued for its role as a key intermediate in advanced organic synthesis, enabling the construction of complex molecular architectures. It is primarily sought after by research institutions and industrial R&D departments in the pharmaceutical, agrochemical, and specialty chemical sectors for applications in medicinal chemistry, ligand synthesis, and material science.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates, particularly in kinase inhibitor and other targeted therapy research.
• Agrochemical Synthesis: Used in the development of advanced pesticides, herbicides, and plant growth regulators, leveraging its reactivity to create novel bioactive molecules.
• Ligand and Catalyst Precursor: Serves as a starting material for synthesizing specialized ligands for transition metal catalysis and organometallic complexes.
• Click Chemistry Reagent: Its terminal alkyne group makes it suitable for Huisgen 1,3-dipolar cycloaddition reactions (click chemistry) to create triazole linkages in bioconjugation and polymer chemistry.
• Material Science Research: Employed in the development of functional polymers, dendrimers, and advanced organic materials with tailored properties.
• Chemical Biology Probes: Used to create molecular probes for studying biological processes and enzyme activity.

Basic Information

Product Name	1-Dimethylamino-2-Propyne
CAS No.	7223-38-3
Molecular Formula	C5H9N
Molecular Weight	83.13 g/mol
Synonyms	N,N-Dimethylpropargylamine; 3-(Dimethylamino)-1-propyne; Propargyl dimethylamine; Dimethylpropargylamine; N,N-Dimethyl-2-propyn-1-amine; 2-Propyn-1-amine, N,N-dimethyl-; DMAPA (common abbreviation)
EINECS	230-603-9

Quality Control

Our 1-Dimethylamino-2-Propyne is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specified parameters. We support cGMP and ISO 9001 standards for research and industrial-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation and oxidation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Total impurities ≤ 3.0%
Density (at 20°C)	0.80 - 0.85 g/mL
Refractive Index (n20/D)	1.420 - 1.430

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.