Description

1,3,5[10]-Estratriene-3,16Alpha,17Beta-Trihydroxy 17-Glucuronide is a high-purity conjugated metabolite of estriol, where the glucuronic acid moiety enhances its water solubility and facilitates excretion. This compound is critical for research and development in endocrinology and pharmaceutical sciences, serving as a key reference standard and biochemical tool. It is primarily required by analytical laboratories, pharmaceutical R&D departments, and manufacturers of diagnostic kits for hormone analysis and metabolic studies.

Application

• Pharmaceutical Reference Standard: Used for the calibration and validation of analytical methods (HPLC, LC-MS) in drug development and quality control.
• Endocrinology Research: A vital biochemical tool for studying estrogen metabolism, conjugation pathways, and hormone clearance mechanisms.
• Diagnostic Kit Manufacturing: Serves as a critical component in the production of immunoassays and test kits for measuring estrogen metabolites in clinical samples.
• Metabolite Identification: Used as a confirmed standard in mass spectrometry libraries for identifying estrogen-related compounds in complex biological matrices.
• Toxicology Studies: Employed in research investigating the pharmacokinetics, bioavailability, and excretion profiles of steroid hormones.

Basic Information

Product Name	1,3,5[10]-Estratriene-3,16Alpha,17Beta-Trihydroxy 17-Glucuronide
CAS No.	7219-89-8
Molecular Formula	C24H32O10
Molecular Weight	480.51 g/mol
Synonyms	Estriol 17-Glucuronide; Estriol 17-β-D-Glucuronide; E3-17G; 16α-Hydroxyestriol 17-Glucuronide; NSC 113939; 3,16α,17β-Trihydroxyestra-1,3,5(10)-trien-17-yl β-D-Glucopyranosiduronic Acid
EINECS	Contact for details

Quality Control

Our 1,3,5[10]-Estratriene-3,16Alpha,17Beta-Trihydroxy 17-Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for research and diagnostic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept in a dry environment and sealed immediately after use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.