Description

Chloroacetyl-Dl-Leucine is a key chiral building block and protected amino acid derivative, essential for advanced organic synthesis. Its primary value lies in serving as a versatile intermediate for the preparation of peptides, peptidomimetics, and other bioactive compounds, enabling precise molecular construction. This high-purity intermediate is critically needed by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers focused on developing new therapeutic agents and conducting sophisticated chemical research.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used as a protected leucine derivative in solid-phase and solution-phase peptide synthesis (SPPS).
• Bioconjugation & Linker Chemistry: The chloroacetyl group provides a reactive handle for conjugation to antibodies, proteins, or other biomolecules.
• Protease Inhibitor Development: Serves as a core scaffold for designing and synthesizing enzyme inhibitors targeting proteases.
• Chemical Biology Research: Employed in the study of protein-protein interactions and the development of molecular probes.
• Fine Chemical Synthesis: A building block for creating complex organic molecules with specific chiral centers.

Basic Information

Product Name	Chloroacetyl-Dl-Leucine
CAS No.	7154-83-8
Molecular Formula	C8H14ClNO3
Molecular Weight	207.65 g/mol
Synonyms	2-Chloro-N-[(RS)-4-methyl-1-oxopentan-2-yl]acetamide; DL-2-Chloroacetamido-4-methylpentanoic acid; N-Chloroacetyl-DL-leucine; (RS)-2-(2-Chloroacetamido)-4-methylpentanoic acid; Chloroacetylleucine; N-(2-Chloroacetyl)-DL-leucine; DL-Leucine, N-chloroacetyl-; 4-Methyl-2-(2-chloroacetamido)pentanoic acid
EINECS	Contact for details

Quality Control

Our Chloroacetyl-Dl-Leucine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and chiral purity, and is supplied with a detailed Certificate of Analysis (COA). We adhere to cGMP principles where applicable to support our customers in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to prevent absorption of atmospheric moisture, which can affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	DL-mixture (approx. 50:50)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.