Description

Doxapram Hydrochloride Monohydrate is a potent respiratory stimulant belonging to the pyrrolidinone class of compounds. This pharmaceutical-grade active pharmaceutical ingredient (API) is critical for ensuring reliable and controlled respiratory support in clinical settings. It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in the development and production of critical care medications and central nervous system stimulants.

Application

• Pharmaceutical API: Primary use as the active ingredient in injectable formulations for the treatment of post-anesthetic respiratory depression and drug-induced central nervous system depression.
• Critical Care Medicine: Manufacture of emergency medications used in hospital settings to stimulate breathing in patients with acute respiratory failure.
• Veterinary Medicine: Component in veterinary pharmaceuticals for respiratory stimulation in animals.
• Pharmacological Research: A valuable reference standard and tool compound in studies focusing on respiratory control, analeptic agents, and central nervous system pharmacology.
• Analytical Standard: Used as a high-purity certified reference material (CRM) in quality control laboratories for HPLC, LC-MS, and other analytical methods.

Basic Information

Product Name	Doxapram Hydrochloride Monohydrate
CAS No.	7081-53-0
Molecular Formula	C24H31ClN2O2 • HCl • H2O
Molecular Weight	473.44 g/mol
Synonyms	Doxapram HCl Monohydrate; 1-Ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone Hydrochloride Monohydrate; Dopram; AHR-619; Docatone; Stimulex; Respirex; Doxapril; Doxapram Hydrochloride Hydrate
EINECS	230-400-1

Quality Control

Our Doxapram Hydrochloride Monohydrate is manufactured under strict quality management systems. Each batch is tested to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines. A comprehensive Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, water content, and microbiological attributes is provided with every shipment to guarantee traceability and compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. The container should be kept tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	3.0% - 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Sulfated Ash	≤ 0.1%
Microbiological Enumeration	Complies with Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.