Description

Quinidine Gluconate is a quaternary ammonium salt derivative of the alkaloid quinidine, widely recognized for its role as a class Ia antiarrhythmic agent. This high-purity pharmaceutical intermediate is critical for ensuring the efficacy and safety of cardiac medications. It is primarily utilized by pharmaceutical manufacturers and research institutions in the development and production of antiarrhythmic drugs and related cardiovascular therapies.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active component in prescription antiarrhythmic medications for treating atrial fibrillation and other cardiac arrhythmias.
• Reference Standard: Serves as a certified reference material (CRM) in analytical laboratories for quality control, method validation, and regulatory compliance testing.
• Biochemical Research: Used in pharmacological and electrophysiological studies to investigate ion channel (particularly sodium channel) blockade and cardiac cell membrane stabilization.
• Formulation Development: Employed in the R&D of various drug delivery systems, including injectable solutions and sustained-release formulations.
• Pharmacopoeial Grade Manufacturing: Essential for producing drug substances that comply with international pharmacopoeia standards such as USP (United States Pharmacopeia) and EP (European Pharmacopoeia).

Basic Information

Product Name	Quinidine Gluconate
CAS No.	7054-25-3
Molecular Formula	C₂₉H₄₄N₂O₈
Molecular Weight	560.68 g/mol
Synonyms	Quinidine D-gluconate; (9S)-6'-Methoxycinchonan-9-ol mono-D-gluconate; Cinchonan-9-ol, 6'-methoxy-, (9S)-, mono-D-gluconate; Gluconic acid, quinidine salt; Quinidine gluconate salt; Quinidine hydrogen D-gluconate; NSC 529070
EINECS	230-329-6

Quality Control

Our Quinidine Gluconate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with pharmaceutical-grade requirements. A Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and other critical parameters is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Specific Rotation	+55° to +60° (c=2 in water)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.