Description

o-[4-Hydroxy-3,5-Di(131I)Iodophenyl]-3,5-Di(131I)Iodo-L-Tyrosine is a high-specific-activity, radioiodinated derivative of tyrosine, designed for advanced research and diagnostic applications. This compound is critical for developing and calibrating sensitive assays in nuclear medicine and radiopharmaceutical research. It is primarily utilized by pharmaceutical R&D teams, radiochemistry laboratories, and diagnostic imaging centers requiring precise radiolabeled tracers.

Application

• Radiopharmaceutical Precursor: Serves as a key intermediate in the synthesis of novel iodine-131 labeled diagnostic and therapeutic agents.
• Metabolic Pathway Tracer: Used in research to study tyrosine metabolism, thyroid hormone synthesis, and protein turnover using radioisotopic techniques.
• In Vitro Diagnostic (IVD) Development: Essential for the development and calibration of radioimmunoassays (RIA) and other ligand-binding assays requiring high-specific-activity labels.
• Molecular Imaging Probe: Acts as a building block for creating targeted probes for SPECT imaging research, leveraging the gamma emission of Iodine-131.
• Biochemical Research: Employed in studies investigating receptor-ligand interactions, enzyme activity, and cellular uptake mechanisms where a radiolabel is required.
• Quality Control Standard: Used as a reference standard in laboratories to ensure the accuracy and precision of radiochemical purity analyses.

Basic Information

Item	Detail
Product Name	o-[4-Hydroxy-3,5-Di(131I)Iodophenyl]-3,5-Di(131I)Iodo-L-Tyrosine
CAS No.	7019-69-4
Molecular Formula	C15H10131I4NO4
Molecular Weight	Contact for details (Variable due to 131I specific activity)
Synonyms	3,5-Diiodo-L-tyrosine, 3',5'-diiodo-4'-hydroxy derivative; L-Tyrosine, O-[4-hydroxy-3,5-di(131I)iodophenyl]-3,5-di(131I)iodo-; Radioiodinated L-Tyrosine derivative; I-131 labeled tyrosine; (131I)Iodotyrosine; Thyroid hormone synthesis intermediate; Radiolabeled amino acid tracer
EINECS	Contact for details

Quality Control

Every batch of o-[4-Hydroxy-3,5-Di(131I)Iodophenyl]-3,5-Di(131I)Iodo-L-Tyrosine is manufactured and controlled under a strict quality management system. Radiochemical purity and specific activity are determined via validated methods such as radio-HPLC and gamma counting. Certificates of Analysis (COA) detailing radionuclidic purity, radiochemical purity, specific activity, and solvent content are provided with each shipment to ensure compliance with research and development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C in a dedicated radioactive materials storage area. The product is strictly light-sensitive (protect from all light exposure). Users must adhere to all local, national, and international regulations for the safe handling, storage, and disposal of radioactive materials.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow solution
Identification (HPLC)	Retention time corresponds to reference standard
Radiochemical Purity (RPC-HPLC)	≥ 95%
Radionuclidic Purity (Gamma Spectrometry)	≥ 99% (I-131)
Specific Activity	Contact for details (Carrier-free or specified range available)
Solvent	Ethanol / Water mixture (Specified on COA)
pH	3.0 - 7.0

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.