Description

10-Hydroxyimipramine is a significant metabolite and chemical intermediate derived from the tricyclic antidepressant imipramine. This compound is of critical importance for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the synthesis of novel therapeutic agents. It serves as a key building block for medicinal chemists and analytical scientists in the pharmaceutical, biotechnology, and academic research sectors.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative and qualitative analysis of imipramine and its metabolites in biological matrices and pharmaceutical formulations.
• Metabolite Research: Essential for in-vitro and in-vivo studies investigating the metabolic pathways, bioavailability, and clearance mechanisms of tricyclic antidepressants.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a crucial synthetic intermediate in the development and production of new psychotropic drugs and related compounds.
• Analytical Method Development: Employed for calibrating equipment and validating analytical methods such as HPLC, LC-MS, and GC-MS in quality control and bioanalytical laboratories.
• Pharmacological Studies: Utilized in receptor binding assays and other preclinical research to understand the structure-activity relationships (SAR) of tricyclic compounds.

Basic Information

Product Name	10-Hydroxyimipramine
CAS No.	796-28-1
Molecular Formula	C19H24N2O
Molecular Weight	296.41 g/mol
Synonyms	10-Hydroxyimipramine; 2-Chloro-10-(3-((2-hydroxyethyl)amino)propyl)-5,10-dihydrodibenzo[b,e][1,4]diazepine; 10-Hydroxy-Imipramine; Desipramine, 10-hydroxy-; 10-OH-Imipramine; Imipramine metabolite; 5-(3-Dimethylaminopropyl)-10,11-dihydro-5H-dibenz[b,f]azepin-10-ol (related structure); NSC 113935
EINECS	Contact for details

Quality Control

Our 10-Hydroxyimipramine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assessment by HPLC, and determination of residual solvents and impurities to ensure it meets high-purity standards suitable for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.