Description

1-(4-Trifluoromethylphenyl)-1-Phenylmethyl Chloride is a versatile and high-value organofluorine intermediate. Its core value proposition lies in its trifluoromethylphenyl moiety, which is a critical structural motif for imparting enhanced metabolic stability, lipophilicity, and bioavailability in advanced molecules. This compound is essential for R&D and production chemists in the pharmaceutical and agrochemical sectors, serving as a key building block for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammatory diseases, and oncology.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a building block for fluorine-containing liquid crystals used in high-performance displays (LCDs) due to its ability to modify dielectric anisotropy and viscosity.
• Organic Synthesis & Catalysis: Employed in cross-coupling reactions and as an electrophile in the construction of complex diarylmethane frameworks for material science research.
• Dye & Pigment Industry: Acts as an intermediate for synthesizing specialized fluorinated dyes and pigments with unique color fastness and chemical resistance properties.

Basic Information

Product Name	1-(4-Trifluoromethylphenyl)-1-Phenylmethyl Chloride
CAS No.	787-49-5
Molecular Formula	C14H10ClF3
Molecular Weight	270.68 g/mol
Synonyms	α-Chloro-4-(trifluoromethyl)benzhydryl Chloride; (4-Trifluoromethylphenyl)phenylmethyl Chloride; 1-Chloro-1-(4-trifluoromethylphenyl)-1-phenylethane (common misnomer); Benzhydryl chloride, 4'-(trifluoromethyl)-; 4'-(Trifluoromethyl)benzhydryl chloride; p-Trifluoromethylbenzhydryl chloride; [Chloro(4-trifluoromethylphenyl)methyl]benzene
EINECS	Contact for details

Quality Control

Our 1-(4-Trifluoromethylphenyl)-1-Phenylmethyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.