Description

3-(Trifluoromethoxy)Chlorobenzene is a versatile fluorinated aromatic building block, essential for introducing both trifluoromethoxy and chloro substituents into advanced molecular architectures. Its primary value lies in its role as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs) and agrochemicals, where the trifluoromethoxy group is prized for enhancing metabolic stability and lipophilicity. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex, high-value molecules.

Application

• Pharmaceutical Intermediate: A crucial synthon for the development of novel drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group improves biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display and lighting technologies.
• Polymer & Resin Modification: Incorporated into specialty polymers to impart unique chemical resistance and thermal stability properties.
• Organic Synthesis & Research: A valuable reagent in academic and industrial laboratories for cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution.

Basic Information

Product Name	3-(Trifluoromethoxy)Chlorobenzene
CAS No.	772-49-6
Molecular Formula	C7H4ClF3O
Molecular Weight	196.55 g/mol
Synonyms	1-Chloro-3-(trifluoromethoxy)benzene; m-Chlorophenyl trifluoromethyl ether; 3-Chlorophenyl trifluoromethyl ether; 3-Chloro-α,α,α-trifluoroanisole; (3-Chlorophenoxy)trifluoromethane; Benzene, 1-chloro-3-(trifluoromethoxy)-; 3-Trifluoromethoxychlorobenzene
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethoxy)Chlorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and concentration changes. Recommended storage temperature: 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Density (20°C)	~1.40 g/cm³
Boiling Point	~165-168°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.