Description

(Z-Glu(Obut)-Onp) is a protected glutamic acid derivative, specifically the p-nitrophenyl ester of N-carbobenzoxy-γ-tert-butyl glutamate. This compound serves as a crucial building block in peptide synthesis, where its orthogonal protecting groups allow for selective deprotection and controlled chain elongation. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers engaged in the development of novel peptides, APIs, and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated ester for the efficient incorporation of glutamic acid with side-chain protection.
• Solution-Phase Peptide Chemistry: Used in the synthesis of complex peptide fragments and small proteins.
• Pharmaceutical Intermediate: A key precursor in the production of peptide-based active pharmaceutical ingredients (APIs).
• Bioconjugation: Facilitating the attachment of peptide sequences to other molecules, polymers, or surfaces.
• Research & Development: Employed in academic and industrial labs for exploring new peptide structures and drug candidates.
• Custom Synthesis: Serves as a starting material for the tailored synthesis of specialized glutamic acid-containing compounds.

Basic Information

Product Name	(Z-Glu(Obut)-Onp)
CAS No.	767-08-8
Molecular Formula	C₂₂H₂₄N₂O₈
Molecular Weight	444.44 g/mol
Synonyms	N-Carbobenzoxy-γ-tert-butyl-L-glutamic acid p-nitrophenyl ester; Z-Glu(OtBu)-ONp; Nα-Cbz-L-glutamic acid 1-tert-butyl ester 5-(4-nitrophenyl) ester; Cbz-Glu(OtBu)-ONp; (Z-Glu(OtBu)-ONp); N-Cbz-L-glutamic acid α-tert-butyl ester γ-4-nitrophenyl ester; L-Glutamic acid, N-[(phenylmethoxy)carbonyl]-, 1-(1,1-dimethylethyl) 5-(4-nitrophenyl) ester
EINECS	Contact for details

Quality Control

Our (Z-Glu(Obut)-Onp) is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for demanding research and synthesis applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemicals, and specifications can be aligned with customer-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Specific Rotation	Contact for details
Melting Point	Contact for details
Heavy Metals	<10 ppm
Residual Solvents	Complies with ICH guidelines
Water Content (KF)	<0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.