Description

4-Fluorophenylacetylene is a versatile fluorinated aromatic alkyne building block, essential for advanced organic synthesis. Its unique structure, featuring both a reactive terminal alkyne group and a fluorine-substituted aromatic ring, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries for applications such as drug discovery, ligand synthesis, and the development of functional polymers.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring fluorinated aromatic motifs to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and pesticides where the fluorine atom can improve biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the production of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Click Chemistry Reagent: Ideal for Huisgen 1,3-dipolar cycloaddition (copper-catalyzed azide-alkyne cycloaddition) reactions to create triazole linkages in bioconjugation and polymer chemistry.
• Ligand and Catalyst Development: Employed in the preparation of sophisticated ligands for transition metal catalysis, enabling more efficient and selective synthetic transformations.
• Fluorine-18 Radiochemistry: Potential precursor for the synthesis of PET (Positron Emission Tomography) imaging agents, although typically non-radioactive precursors are used.

Basic Information

Product Name	4-Fluorophenylacetylene
CAS No.	766-98-3
Molecular Formula	C8H5F
Molecular Weight	120.12 g/mol
Synonyms	1-Ethynyl-4-fluorobenzene; p-Fluorophenylacetylene; 4-Fluoroethynylbenzene; (4-Fluorophenyl)ethyne; 4-Fluorobenzeneacetylene; 4-Fluoro-1-ethynylbenzene; 766-98-3; p-Fluoroethynylbenzene
EINECS	212-178-3

Quality Control

Our 4-Fluorophenylacetylene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and oxidizing agents. Recommended storage temperature is between 2°C and 8°C (refrigerated) for long-term stability, although the product is stable at room temperature for shorter periods. Keep container tightly sealed when not in use to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.