Description

4-Bromophenylacetylene is a versatile and high-purity organic building block, essential for advanced chemical synthesis. This compound is a critical intermediate for constructing complex molecular architectures, particularly in pharmaceutical and materials science research. It is primarily used by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications such as cross-coupling reactions and the synthesis of novel polymers.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those requiring arylacetylene motifs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and plant growth regulators.
• Material Science: Serves as a monomer or cross-linking agent in the production of specialty polymers, conductive materials, and liquid crystals.
• Cross-Coupling Reactions: An excellent substrate for Sonogashira, Heck, and other palladium-catalyzed coupling reactions to form carbon-carbon bonds.
• Organic Synthesis Building Block: Employed in academic and industrial research labs for the construction of complex organic molecules, natural products, and ligands for catalysis.
• Chemical Research: Utilized in developing new synthetic methodologies and as a standard reagent in high-throughput screening.

Basic Information

Product Name	4-Bromophenylacetylene
CAS No.	766-96-1
Molecular Formula	C8H5Br
Molecular Weight	181.03 g/mol
Synonyms	1-Bromo-4-ethynylbenzene; p-Bromophenylacetylene; 4-Ethynylbromobenzene; (4-Bromophenyl)ethyne; 4-Bromoethynylbenzene; p-Bromoethynylbenzene; 4-Bromo-1-ethynylbenzene; Bromo(4-ethynylphenyl)-
EINECS	212-172-6

Quality Control

Our 4-Bromophenylacetylene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.