Description

3-Chlorophenylacetylene is a versatile halogenated alkyne building block essential for advanced organic synthesis. Its terminal alkyne functionality, activated by the electron-withdrawing chloro substituent, makes it a critical reagent for constructing complex molecular architectures via cross-coupling reactions. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries to introduce the 3-chlorophenylacetylene moiety into target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of active pharmaceutical ingredients (APIs) and bioactive molecules through Sonogashira, Glaser, and other metal-catalyzed coupling reactions.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the chlorophenyl group often contributes to biological activity.
• Material Science & Polymer Chemistry: Serves as a monomer or cross-linking agent in the synthesis of conjugated polymers, dendrimers, and specialty resins with tailored electronic or mechanical properties.
• Ligand & Catalyst Development: Employed in the synthesis of novel phosphine or N-heterocyclic carbene (NHC) ligands for asymmetric catalysis and organometallic chemistry.
• Chemical Research & Development: A fundamental building block in academic and industrial R&D for exploring new synthetic methodologies and creating molecular libraries for screening.

Basic Information

Product Name	3-Chlorophenylacetylene
CAS No.	766-83-6
Molecular Formula	C8H5Cl
Molecular Weight	136.58 g/mol
Synonyms	1-Chloro-3-ethynylbenzene; m-Chlorophenylacetylene; 3-Ethynylchlorobenzene; (3-Chlorophenyl)ethyne; 3-Chloroethynylbenzene; m-Chloroethynylbenzene; 1-Ethynyl-3-chlorobenzene
EINECS	212-169-5

Quality Control

Our 3-Chlorophenylacetylene is produced under stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use and away from heat, sparks, and open flames. Keep away from incompatible materials such as strong oxidizers and bases.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.