Description

5-Fluorouracil, [2-14C] CAS NO 766-63-2 is a carbon-14 labeled analog of the widely used antimetabolite and chemotherapeutic agent, 5-fluorouracil. This radiolabeled compound is an essential tool for conducting advanced pharmacokinetic, metabolic, and drug distribution studies in pharmaceutical and biochemical research. It is primarily required by research scientists and quality control laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors for tracer studies and analytical method development.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a radiotracer to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of 5-fluorouracil and related compounds.
• Biochemical Pathway Analysis: Essential for tracing the incorporation of 5-FU into RNA and DNA and studying its mechanism of action as a thymidylate synthase inhibitor.
• Analytical Method Development: Serves as a critical reference standard for developing and validating sensitive detection methods like Liquid Scintillation Counting (LSC) and LC-MS/MS in bioanalytical labs.
• Preclinical Research: Utilized in animal studies to model cancer treatment efficacy and understand tissue-specific drug uptake and clearance.
• Environmental Fate Studies: Applied in research to track the environmental degradation and persistence of fluorouracil compounds.

Basic Information

Product Name	5-Fluorouracil, [2-14C]
CAS No.	766-63-2
Molecular Formula	C4H3FN2O2 (with 14C at position 2)
Molecular Weight	130.08 g/mol (unlabeled)
Synonyms	5-FU-2-14C; [2-14C]-5-Fluorouracil; 5-Fluoro-2,4(1H,3H)-pyrimidinedione-2-14C; 5-Fluoropyrimidine-2,4-dione-2-14C; 5-Fluoro-1H,3H-pyrimidine-2,4-dione-2-14C; NSC-19893 (labeled); Adrucil (labeled reference); Efudex (labeled reference); Fluoroplex (labeled reference)
EINECS	212-161-0 (for unlabeled compound)

Quality Control

Every batch of 5-Fluorouracil, [2-14C] is manufactured and handled under strict quality protocols to ensure isotopic and chemical purity, radiochemical purity, and specific activity consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing specific activity, radiochemical purity (by HPLC), chemical purity, and solvent content are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). For long-term storage, consider conditions recommended for radioactive materials. Store in accordance with all local and national regulations for radioactive substances.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Specific Activity	Contact for details (mCi/mmol)
Radiochemical Purity (HPLC)	≥ 95%
Chemical Purity (HPLC)	≥ 98%
Solvent Content (Residual Solvents)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.