Description

1-Ethynyl-2-Fluorobenzene is a versatile aromatic building block featuring both a reactive ethynyl group and a fluorine substituent. This unique bifunctional structure makes it a critical intermediate for synthesizing complex molecules in advanced research and development. It is essential for pharmaceutical chemists, agrochemical researchers, and material scientists developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated aromatic scaffolds and alkyne-based click chemistry.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the fluorine atom enhances biological activity and metabolic stability.
• Material Science: Serves as a monomer or cross-linking agent in the production of specialty polymers, resins, and advanced organic electronic materials.
• Ligand & Catalyst Development: Employed in organometallic chemistry to create novel ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Research: A valuable reagent for studying structure-activity relationships (SAR) and introducing fluorine atoms into complex molecular architectures.
• Diagnostic Probe Synthesis: Used in the development of radiolabeled compounds and fluorescent tags for imaging and diagnostic applications.

Basic Information

Item	Details
Product Name	1-Ethynyl-2-Fluorobenzene
CAS No.	766-49-4
Molecular Formula	C8H5F
Molecular Weight	120.12 g/mol
Synonyms	2-Fluoroethynylbenzene; o-Fluoroethynylbenzene; 2-Fluorophenylacetylene; (2-Fluorophenyl)ethyne; 1-Ethynyl-2-fluorobenzene; 2-Fluoro-1-ethynylbenzene; 2-Fluorobenzeneacetylene; 2-Fluorophenylacetylene
EINECS	Contact for details

Quality Control

Our 1-Ethynyl-2-Fluorobenzene is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature and sensitivity to strong alkalis, keep away from heat, sparks, and incompatible materials. For long-term storage, consider maintaining under an inert atmosphere.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.