Description

3,3-Difluoro-1,1,1,3-Tetrachloropropan-2-One is a highly reactive halogenated ketone building block, specifically engineered for advanced synthetic chemistry. Its unique structure, featuring both fluorine and chlorine atoms, makes it a critical intermediate for introducing difluoromethyl and other fluorinated motifs into target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries seeking to enhance the metabolic stability and bioavailability of new active ingredients. The CAS number for this product is 758-41-8.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel fluorinated drug candidates, particularly in protease inhibitors and kinase modulators.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where fluorination improves lipophilicity and environmental persistence.
• Material Science Precursor: Serves as a building block for specialty polymers and liquid crystals with tailored thermal and chemical resistance properties.
• Fluorinating Agent: Acts as a source of difluorocarbene or other reactive fluorinated species in organic transformations.
• Chemical Research: Employed in academic and industrial R&D for exploring new fluorination methodologies and creating complex molecular architectures.

Basic Information

Item	Detail
Product Name	3,3-Difluoro-1,1,1,3-Tetrachloropropan-2-One
CAS No.	758-41-8
Molecular Formula	C3Cl4F2O
Molecular Weight	229.83 g/mol
Synonyms	1,1,1,3-Tetrachloro-3,3-difluoroacetone; 3,3-Difluoro-1,1,1,3-tetrachloroacetone; Tetrachlorodifluoroacetone; Perchlorodifluoroacetone; 1,1,1,3-Tetrachloro-3,3-difluoropropan-2-one; 2-Propanone, 1,1,1,3-tetrachloro-3,3-difluoro-; DFTP; TCDFA
EINECS	212-060-4

Quality Control

Every batch of 3,3-Difluoro-1,1,1,3-Tetrachloropropan-2-One is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place, away from incompatible materials such as strong bases and fluorides. Recommended storage temperature is 2-8°C for long-term stability. Keep container tightly sealed in a dry inert atmosphere to minimize moisture absorption and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.