Description

S-(-)-Nornicotine is the S-enantiomer of nornicotine, a key secondary alkaloid and metabolite of nicotine. This chiral compound is of significant interest in pharmaceutical and biochemical research due to its distinct biological activity profile compared to its R-enantiomer. It serves as a critical intermediate and reference standard for the development of novel therapeutics and research into nicotinic acetylcholine receptor (nAChR) interactions. This high-purity material is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and life science sectors.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates targeting neurological pathways.
• Biochemical Research: Used as a reference standard and probe in studies of nicotinic acetylcholine receptors (nAChRs) and neurotransmitter systems.
• Metabolite Studies: Employed in analytical and pharmacokinetic research as a standard for nicotine metabolism.
• Agrochemical Research: Investigated as a lead compound or intermediate for the development of new plant growth regulators or insecticides.
• Neuroscience: Utilized in receptor binding assays and behavioral studies to understand the effects of nicotine derivatives.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for HPLC, GC-MS, and LC-MS methods in analytical laboratories.

Basic Information

Product Name	S-(-)-Nornicotine
CAS No.	746-86-1
Molecular Formula	C9H12N2
Molecular Weight	148.21 g/mol
Synonyms	(S)-Nornicotine; (-)-Nornicotine; (S)-1-Methyl-2-(3-pyridyl)pyrrolidine; (S)-3-(2-Pyrrolidinyl)pyridine; S-Nornicotine; L-Nornicotine; (2S)-1-Methyl-2-(pyridin-3-yl)pyrrolidine; Demethylnicotine
EINECS	212-030-8

Quality Control

Our S-(-)-Nornicotine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are provided with every shipment. We support compliance with relevant regulatory frameworks for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent oxidation. Keep the container tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (S-enantiomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.