Description

5-[4-(Trifluoromethyl)Phenyl]-4,5-Dihydro-1,3-Oxazol-2-Amine is a specialized heterocyclic organic compound featuring a dihydrooxazole (oxazoline) core substituted with a trifluoromethylphenyl group and an amine functionality. This structure makes it a valuable key intermediate and building block in advanced synthetic chemistry, particularly for the development of pharmaceuticals and agrochemicals. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, crop protection, and fine chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Used as a building block for developing advanced herbicides, fungicides, and insecticides, leveraging the stability imparted by the trifluoromethyl group.
• Ligand and Catalyst Development: The oxazoline ring and amine group make it a suitable precursor for chiral ligands used in asymmetric catalysis.
• Material Science Research: Employed in the research and development of specialty polymers and advanced organic materials with specific electronic or structural properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and enzyme functions.
• Custom Synthesis and Contract Manufacturing: A key starting material for custom synthesis projects undertaken by CDMOs (Contract Development and Manufacturing Organizations).

Basic Information

Product Name	5-[4-(Trifluoromethyl)Phenyl]-4,5-Dihydro-1,3-Oxazol-2-Amine
CAS No.	720-76-3
Molecular Formula	C10H9F3N2O
Molecular Weight	230.19 g/mol
Synonyms	2-Amino-5-[4-(trifluoromethyl)phenyl]-4,5-dihydro-1,3-oxazole; 5-(4-Trifluoromethylphenyl)-4,5-dihydrooxazol-2-ylamine; 2-Oxazolinamine, 5-[4-(trifluoromethyl)phenyl]-4,5-dihydro-; 5-(p-Trifluoromethylphenyl)-2-amino-2-oxazoline; 720-76-3; 5-(4-Trifluoromethylphenyl)-2-amino-4,5-dihydrooxazole
EINECS	Contact for details

Quality Control

Our production of 5-[4-(Trifluoromethyl)Phenyl]-4,5-Dihydro-1,3-Oxazol-2-Amine adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research and industrial use. All materials are fully characterized, and Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are provided with each shipment. We support our clients' regulatory needs and are committed to cGMP principles where required for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.