Description

1(3H)-Isobenzofuranone, 5-Fluoro- is a high-purity fluorinated organic intermediate, specifically a halogenated phthalide derivative. This compound is valued for its role as a versatile building block in the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily sought by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and agrochemical industries for constructing active pharmaceutical ingredients (APIs) and other specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, including potential central nervous system (CNS) agents and anti-inflammatory compounds.
• Agrochemical Synthesis: Used in the research and development of novel fluorinated pesticides and herbicides, where the fluorine atom can enhance biological activity and stability.
• Material Science Research: Serves as a monomer or building block for developing specialty polymers and advanced organic materials with tailored properties.
• Organic Synthesis & Catalysis: Employed in academic and industrial laboratories for methodological studies in fluorination chemistry and as a substrate for developing new catalytic reactions.
• Ligand & Chelator Development: The phthalide core can be functionalized to create novel ligands for metal complexes used in catalysis or imaging.

Basic Information

Product Name	1(3H)-Isobenzofuranone, 5-Fluoro-
CAS No.	700-85-6
Molecular Formula	C8H5FO2
Molecular Weight	152.12 g/mol
Synonyms	5-Fluorophthalide; 5-Fluoro-1(3H)-isobenzofuranone; 5-Fluoroisobenzofuran-1(3H)-one; 5-Fluoro-3H-isobenzofuran-1-one; 5-Fluorophthalic anhydride lactone; 5-Fluoro-2-benzofuran-1(3H)-one; 5-Fluoro-1,3-dihydroisobenzofuran-1-one
EINECS	Contact for details

Quality Control

Our 1(3H)-Isobenzofuranone, 5-Fluoro- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.