Description

R- 4-Oxide-2,6-Bis([1,1'-Biphenyl]-4-Yl)-4-Hydroxy-Dinaphtho[2,1-D:1',2'-F][1,3,2]Dioxaphosphepin CAS NO 699006-54-7 is a sophisticated chiral organophosphorus compound characterized by its unique dinaphthodioxaphosphepin core structure. This compound is valued for its role as a high-performance ligand or catalyst precursor in asymmetric synthesis, enabling the production of enantiomerically pure pharmaceuticals and fine chemicals. It is essential for R&D and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control.

Application

• Asymmetric Catalysis: Serving as a key chiral ligand or precursor for transition metal catalysts in enantioselective hydrogenation, cross-coupling, and C-H activation reactions.
• Pharmaceutical Intermediate Synthesis: Enabling the production of single-enantiomer active pharmaceutical ingredients (APIs) for drugs targeting central nervous system, cardiovascular, and metabolic diseases.
• Agrochemical Development: Used in the research and synthesis of chiral pesticides and herbicides with improved efficacy and environmental profiles.
• Advanced Material Research: Potential application in the development of chiral polymers, liquid crystals, or molecular recognition systems.
• Academic & Industrial R&D: A valuable tool for methodological development in organic and organometallic chemistry laboratories.
• Process Chemistry Optimization: Implementation in scale-up processes to improve yield and enantiomeric excess (ee) in commercial manufacturing.

Basic Information

Product Name	R- 4-Oxide-2,6-Bis([1,1'-Biphenyl]-4-Yl)-4-Hydroxy-Dinaphtho[2,1-D:1',2'-F][1,3,2]Dioxaphosphepin
CAS No.	699006-54-7
Molecular Formula	C52H34O4P
Molecular Weight	753.80 g/mol
Synonyms	(R)-4-Hydroxy-2,6-bis([1,1'-biphenyl]-4-yl)-dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin 4-oxide; (R)-BIPHEP-OH oxide; (R)-2,6-Bis(4-biphenylyl)-4-hydroxy-dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin 4-oxide; R-BINAP(O)OH biphenyl derivative; Chiral phosphine oxide ligand; R- BIPHEP monophosphine oxide; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our R- 4-Oxide-2,6-Bis([1,1'-Biphenyl]-4-Yl)-4-Hydroxy-Dinaphtho[2,1-D:1',2'-F][1,3,2]Dioxaphosphepin is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for chiral purity and assay, NMR for structural confirmation, and elemental analysis, to ensure it meets the high standards required for catalytic and synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data and enantiomeric excess (ee) are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider using an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.