Description

Ethyl 2,2-Difluoro-2-(3-Fluorophenyl)Acetate is a high-purity fluorinated organic ester building block of significant importance in advanced chemical synthesis. Its value lies in its unique difluoroacetate structure, which serves as a versatile intermediate for introducing fluorine atoms into complex molecules, thereby modulating their physical, chemical, and biological properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients with enhanced metabolic stability, bioavailability, and lipophilicity.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of modern pesticides and herbicides, where the introduction of fluorine atoms can improve efficacy, environmental stability, and selectivity.
• Material Science Precursor: Serves as a monomer or modifier in the development of specialty polymers and advanced materials with tailored surface properties and chemical resistance.
• Liquid Crystal & OLED Materials: Employed in the synthesis of fluorinated components for electronic display technologies, contributing to improved dielectric anisotropy and performance.
• Organic Synthesis Reagent: Acts as a versatile reagent in nucleophilic substitution and coupling reactions for constructing complex fluorinated molecular architectures in medicinal chemistry.

Basic Information

Item	Details
Product Name	Ethyl 2,2-Difluoro-2-(3-Fluorophenyl)Acetate
CAS No.	698378-81-3
Molecular Formula	C10H9F3O2
Molecular Weight	218.17 g/mol
Synonyms	Ethyl 2,2-Difluoro-2-(3-fluorophenyl)acetate; 2,2-Difluoro-2-(3-fluorophenyl)acetic Acid Ethyl Ester; 3-Fluorophenyl(difluoro)acetic Acid Ethyl Ester; Ethyl (3-Fluorophenyl)difluoroacetate; Ethyl α,α-Difluoro-3-fluorophenylacetate; Acetic acid, 2,2-difluoro-2-(3-fluorophenyl)-, ethyl ester; 698378-81-3
EINECS	Contact for details

Quality Control

Our Ethyl 2,2-Difluoro-2-(3-Fluorophenyl)Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our production adheres to cGMP guidelines where applicable, ensuring reliability for your most demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids, bases, and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.