Description

Lumiracoxib Acyl--D-Glucuronide is a key metabolite of the selective COX-2 inhibitor lumiracoxib, formed via glucuronidation. This compound is of significant importance in pharmaceutical research and development, particularly for metabolism and pharmacokinetic studies. It is primarily needed by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in drug discovery, bioanalytical method development, and regulatory compliance testing.

Application

• Reference Standard for Bioanalysis: Serves as a critical certified reference material (CRM) for the quantification of lumiracoxib and its metabolites in biological matrices using LC-MS/MS or HPLC.
• Pharmacokinetic & Metabolism Studies: Used to investigate the metabolic pathways, clearance rates, and exposure levels of lumiracoxib in preclinical and clinical research.
• Drug Impurity Profiling: Employed as an impurity standard to identify and quantify the acyl glucuronide metabolite in active pharmaceutical ingredient (API) batches, ensuring product purity and safety.
• Toxicology Assessment: Aids in studying the potential reactivity and stability of acyl glucuronide metabolites, which is vital for understanding drug safety profiles.
• Method Development & Validation: Essential for developing, optimizing, and validating robust analytical methods in compliance with ICH, FDA, and EMA guidelines.
• Stability Indicating Assays: Used to monitor the degradation products of lumiracoxib under various stress conditions, supporting formulation stability studies.

Basic Information

Product Name	Lumiracoxib Acyl--D-Glucuronide
CAS No.	697287-17-5
Molecular Formula	C25H24Cl2N2O9
Molecular Weight	567.37 g/mol
Synonyms	Lumiracoxib Acyl Glucuronide; Lumiracoxib 1-O-β-Acyl Glucuronide; 2-[(2,6-Dichlorophenyl)amino]-5-methylbenzeneacetic acid β-1-O-Acyl Glucuronide; COX189 Acyl Glucuronide; Lumiracoxib Glucuronide Metabolite; Prexige Acyl Glucuronide; (2-[(2,6-Dichlorophenyl)amino]-5-methylphenyl)acetic acid 1-(β-D-Glucopyranuronosyl) ester
EINECS	Contact for details

Quality Control

Our Lumiracoxib Acyl--D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous identity confirmation, purity analysis, and impurity profiling using advanced techniques like HPLC, LC-MS, and NMR to ensure compliance with high-purity reference standard requirements. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your research and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, controlled environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.