Description

2-{2-[(2S,5S)-2,5-Dimethyl-1-Phospholano]Phenyl}1,3-Dioxolane, Min. 97% is a high-purity, chiral phosphine ligand with a dioxolane-protected aldehyde group, essential for enabling highly selective and efficient catalytic transformations. Its value lies in providing superior stereocontrol in asymmetric synthesis, which is critical for producing enantiomerically pure intermediates in pharmaceutical and fine chemical manufacturing. This compound is specifically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-performance ligands for metal-catalyzed cross-coupling and hydrogenation reactions.

Application

• As a chiral ligand in asymmetric metal-catalyzed reactions, including hydrogenation, hydroformylation, and cross-coupling.
• For the synthesis of enantiomerically pure pharmaceutical intermediates, such as active pharmaceutical ingredients (APIs) for central nervous system and cardiovascular drugs.
• In the development of novel catalytic systems for academic and industrial research in organic synthesis.
• For the production of specialty agrochemicals requiring specific stereochemistry for enhanced biological activity.
• As a key building block or precursor in the synthesis of more complex phosphine ligands with tailored properties.
• In process chemistry for the scale-up and optimization of catalytic routes to chiral molecules.

Basic Information

Product Name	2-{2-[(2S,5S)-2,5-Dimethyl-1-Phospholano]Phenyl}1,3-Dioxolane, Min. 97%
CAS No.	695816-47-8
Molecular Formula	C15H21O2P
Molecular Weight	264.30 g/mol
Synonyms	(2S,5S)-2,5-Dimethyl-1-(2-(1,3-dioxolan-2-yl)phenyl)phospholane; (S,S)-2,5-Dimethyl-1-(2-(1,3-dioxolan-2-yl)phenyl)phospholane; DMPP-Dioxolane; (S,S)-DMPP-Diox; Chiral Dioxolanylphospholane Ligand; 2-[2-[(2S,5S)-2,5-Dimethylphospholan-1-yl]phenyl]-1,3-dioxolane; (2S,5S)-1-[2-(1,3-Dioxolan-2-yl)phenyl]-2,5-dimethylphospholane
EINECS	Contact for details

Quality Control

Our 2-{2-[(2S,5S)-2,5-Dimethyl-1-Phospholano]Phenyl}1,3-Dioxolane is manufactured under strict quality systems to ensure batch-to-batch consistency and high chiral purity. Each lot undergoes rigorous analytical testing, including HPLC for assay and enantiomeric excess (e.e.) determination, NMR for structural confirmation, and Karl Fischer titration for moisture content. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) in a cool, dry place at 2-8°C to maximize shelf life. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	Min. 97.0%
Enantiomeric Excess (HPLC)	Min. 99.0% e.e.
Water Content (KF)	Max. 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.