Description

1H-Imidazole-4-Aceticacid,α-Amino-,Methylester,(Alphar)-(9Ci) is a specialized, high-purity chiral building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel pharmaceuticals and bioactive molecules, particularly those targeting neurological and metabolic pathways. Pharmaceutical R&D laboratories and fine chemical manufacturers need this precise stereoisomer to ensure the efficacy and safety of their final active pharmaceutical ingredients (APIs). Its structural features make it invaluable for constructing complex heterocyclic frameworks.

Application

• Pharmaceutical Intermediate: Critical chiral synthon for the research and production of potential drug candidates, especially in neurology and enzymology.
• Peptidomimetic Research: Serves as a constrained amino acid analog for designing novel peptide-like compounds with enhanced stability and biological activity.
• Ligand Synthesis for Catalysis: Used in the development of specialized ligands for asymmetric catalysis and metal complexation.
• Bioconjugation Chemistry: Employed in creating linkers and probes for bioconjugation applications in diagnostic and therapeutic fields.
• Academic & Industrial R&D: Fundamental building block in medicinal chemistry programs for exploring new chemical entities and structure-activity relationships (SAR).
• Reference Standard: Sourced for use as an analytical standard in quality control laboratories to ensure purity and identity of related substances.

Basic Information

Product Name	1H-Imidazole-4-Aceticacid,α-Amino-,Methylester,(Alphar)-(9Ci)
CAS No.	695811-28-0
Molecular Formula	C7H11N3O2
Molecular Weight	169.18 g/mol
Synonyms	(αR)-α-Amino-1H-imidazole-4-acetic acid methyl ester; Methyl (R)-2-amino-2-(1H-imidazol-4-yl)acetate; (R)-2-Amino-2-(1H-imidazol-4-yl)acetic acid methyl ester; L-Histidine methyl ester analog; 4-Imidazoleacetic acid, α-amino-, methyl ester, (αR)-; (R)-Methyl 2-amino-2-(1H-imidazol-4-yl)acetate; α-amino-imidazole-4-acetic acid methyl ester (R-enantiomer)
EINECS	Contact for details

Quality Control

Our production of 1H-Imidazole-4-Aceticacid,α-Amino-,Methylester,(Alphar)-(9Ci) adheres to stringent quality management systems, ensuring batch-to-batch consistency for critical R&D and cGMP manufacturing applications. Each lot undergoes comprehensive analytical characterization, including chiral purity verification, to meet the exacting standards of the pharmaceutical industry. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and opened under controlled conditions to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.