Description

Ceftolozane Sulfate is a critical pharmaceutical intermediate and the sulfate salt form of the advanced cephalosporin antibiotic, ceftolozane. This compound is essential for the synthesis of potent antibacterial agents, particularly in combination with tazobactam, to combat serious multi-drug resistant infections. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of next-generation antibiotics targeting Gram-negative pathogens, including complicated urinary tract and intra-abdominal infections.

Application

• Active Pharmaceutical Ingredient (API) for the synthesis of the antibiotic Ceftolozane.
• Key intermediate in the manufacturing of combination drug products, such as Ceftolozane/Tazobactam.
• Research and development of novel antibacterial agents and therapeutic formulations.
• Reference standard for analytical method development and quality control in pharmaceutical laboratories.
• Production of clinical trial materials for evaluating new antibiotic therapies.

Basic Information

Product Name	Ceftolozane Sulfate
CAS No.	689293-68-3
Molecular Formula	C₂₃H₃₀N₁₂O₈S₂ • xH₂SO₄
Molecular Weight	Contact for details
Synonyms	Ceftolozane Sulphate; (6R,7R)-3-[(5-Amino-4-{[(2-aminoethyl)carbamoyl]amino}-1-methyl-1H-pyrazol-2-ium-2-yl)methyl]-7-{[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-ethoxyiminoacetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate sulfate; CXA-101 Sulfate; FR264205 Sulfate; Zerbaxa Intermediate
EINECS	Contact for details

Quality Control

Our Ceftolozane Sulfate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identification by IR and NMR spectroscopy, and stringent controls for residual solvents and impurities to ensure it meets high-grade pharmaceutical standards. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH limits
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.