Description

Pyrrolidine, 1-(2,2,3,3,3-Pentafluoro-1-Oxopropyl)- (9Ci) is a specialized fluorinated pyrrolidine derivative, a high-value intermediate in advanced organic synthesis. Its core value proposition lies in its unique pentafluoropropionyl group, which introduces significant lipophilicity and metabolic stability into target molecules, making it a critical building block for modern pharmaceuticals and agrochemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require precise fluorination to modulate the properties of novel compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of fluorinated drug candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced, fluorinated pesticides and herbicides, where the fluorine atoms enhance biological activity, environmental stability, and uptake.
• Ligand and Catalyst Development: Serves as a precursor for creating novel fluorinated ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of fluorinated polymers and specialty chemicals where surface properties, solvent resistance, and thermal stability are critical.
• Positron Emission Tomography (PET) Tracer Precursor: Potential use in the synthesis of fluorinated radiotracers for medical imaging due to the presence of multiple fluorine atoms.
• Chemical Biology Probe Synthesis: Useful for incorporating stable fluorine tags into biomolecules for studies using techniques like 19F NMR spectroscopy.

Basic Information

Product Name	Pyrrolidine, 1-(2,2,3,3,3-Pentafluoro-1-Oxopropyl)- (9Ci)
CAS No.	686720-34-3
Molecular Formula	C7H8F5NO
Molecular Weight	217.14 g/mol
Synonyms	1-(Pentafluoropropionyl)pyrrolidine; N-Pentafluoropropionylpyrrolidine; 1-(2,2,3,3,3-Pentafluoropropanoyl)pyrrolidine; Pentafluoropropionic acid pyrrolidide; Pyrrolidine, 1-(pentafluoro-1-oxopropyl)-; N-(2,2,3,3,3-Pentafluoropropionyl)pyrrolidine
EINECS	Contact for details

Quality Control

Our Pyrrolidine, 1-(2,2,3,3,3-Pentafluoro-1-Oxopropyl)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatographic purity analysis and identity confirmation, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its chemical nature as a fluoride/strong alkali derivative, it should be kept separate from strong acids and oxidizing agents. Keep container tightly sealed when not in use to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.