Description

L-Proline, 4-(Aminomethyl)-5-Oxo-, (4R)- (9Ci) is a high-purity, non-proteinogenic amino acid derivative with a constrained, bicyclic structure. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile chiral building block for the synthesis of complex bioactive molecules. It is essential for research and production in pharmaceutical development, particularly for creating novel drug candidates targeting neurological and metabolic pathways.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the production of protease inhibitors, enzyme modulators, and other small-molecule therapeutics.
• Peptidomimetics Research: Used to introduce conformational constraints into peptide analogs, enhancing their stability and biological activity.
• Chemical Biology Probes: Serves as a scaffold for developing activity-based probes and inhibitors to study enzyme function.
• Asymmetric Synthesis: Employed as a chiral auxiliary or ligand in catalytic asymmetric reactions to induce stereoselectivity.
• Agrochemical Development: Potential intermediate in the synthesis of novel, biologically active compounds for crop protection.
• Academic & Industrial R&D: Fundamental building block for medicinal chemistry programs and discovery research in both university and corporate laboratories.

Basic Information

Product Name	L-Proline, 4-(Aminomethyl)-5-Oxo-, (4R)- (9Ci)
CAS No.	686287-94-5
Molecular Formula	C7H12N2O3
Molecular Weight	172.18 g/mol
Synonyms	(4R)-4-(Aminomethyl)-5-oxo-L-proline; (4R)-4-(Aminomethyl)-5-oxopyrrolidine-2-carboxylic acid; 4-(Aminomethyl)-5-oxo-L-proline; 4-(Aminomethyl)-5-oxo-(R)-proline; 4-(Aminomethyl)-5-oxo-D-proline (incorrect stereochemistry); 5-Oxo-4-(aminomethyl)-L-proline; A constrained proline derivative; Bicyclic amino acid analog
EINECS	Contact for details

Quality Control

Our L-Proline, 4-(Aminomethyl)-5-Oxo-, (4R)- (9Ci) is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.