Description

[4-[Difluoro(3,4,5-Trifluorophenoxy)Methyl]-3,5-Difluorophenyl]Boronic Acid is a highly fluorinated boronic acid derivative, a crucial building block in modern synthetic chemistry. Its value lies in its unique structure, which enables the precise construction of complex molecules through Suzuki-Miyaura cross-coupling reactions. This advanced intermediate is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the introduction of fluorine atoms can improve efficacy and environmental profile.
• Material Science Research: Employed in the creation of novel organic electronic materials, such as those for OLEDs or semiconductors, where fluorinated aromatic systems are desirable.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and catalysts used in asymmetric synthesis and other advanced catalytic processes.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological systems and drug-target interactions.
• Custom Synthesis and Contract Manufacturing: A critical reagent for fine chemical and custom synthesis organizations serving the life sciences sector.

Basic Information

Product Name	[4-[Difluoro(3,4,5-Trifluorophenoxy)Methyl]-3,5-Difluorophenyl]Boronic Acid
CAS No.	685563-69-3
Molecular Formula	C13H6BF7O3
Molecular Weight	342.00 g/mol
Synonyms	(3,5-Difluoro-4-((3,4,5-trifluorophenoxy)difluoromethyl)phenyl)boronic acid; 4-[(3,4,5-Trifluorophenoxy)difluoromethyl]-3,5-difluorobenzeneboronic acid; Boronic acid, B-[4-[[difluoro(3,4,5-trifluorophenoxy)methyl]-3,5-difluorophenyl]-; [4-(Difluoro-(3,4,5-trifluorophenoxy)methyl)-3,5-difluorophenyl]boronic acid; 3,5-Difluoro-4-((3,4,5-trifluorophenoxy)difluoromethyl)benzeneboronic acid; 685563-69-3 (CAS Name Base); Highly Fluorinated Aryl Boronic Acid Ester Precursor
EINECS	Contact for details

Quality Control

Our [4-[Difluoro(3,4,5-Trifluorophenoxy)Methyl]-3,5-Difluorophenyl]Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake, which can affect reactivity. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.