Description

2-Hydroxy-5-Iodo-Benzonitrile is a versatile halogenated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both a phenolic hydroxyl group and an iodine substituent, makes it a valuable precursor for constructing complex molecules through cross-coupling and functional group transformation reactions. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting enzyme inhibitors and receptor modulators.
• Agrochemical Research: Serves as a building block for developing new herbicides, fungicides, and plant growth regulators with specific modes of action.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for transition metal catalysis and organocatalysts.
• Material Science Precursor: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The iodine atom is an excellent handle for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings to form new carbon-carbon bonds.
• Chemical Derivatization: The hydroxyl and nitrile groups allow for further chemical modifications, such as etherification, esterification, and reduction, to access diverse chemical libraries.

Basic Information

Product Name	2-Hydroxy-5-Iodo-Benzonitrile
CAS No.	685103-95-1
Molecular Formula	C7H4INO
Molecular Weight	244.02 g/mol
Synonyms	5-Iodo-2-hydroxybenzonitrile; 2-Cyano-4-iodophenol; 4-Iodo-2-cyanophenol; 5-Iodosalicylonitrile; 2-Hydroxy-5-iodobenzonitrile; 5-Iodo-2-hydroxybenzenecarbonitrile; 2-Hydroxy-5-iodo-benzonitrile; Benzonitrile, 2-hydroxy-5-iodo-
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-5-Iodo-Benzonitrile is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.