Description

3,4-Difluorophenylboronic Acid-1,3-Propanediol Ester is a high-purity, protected boronic acid derivative, a critical building block in modern synthetic organic chemistry. Its primary value lies in its enhanced stability compared to the free boronic acid, making it an ideal reagent for demanding cross-coupling reactions, particularly Suzuki-Miyaura couplings. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, where the 3,4-difluorophenyl moiety is a key pharmacophore. Its reliable performance under various reaction conditions makes it a preferred choice for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), especially those containing difluorinated aromatic systems for improved metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Suzuki-Miyaura Cross-Coupling: Serves as a stable, air- and moisture-tolerant organoboron reagent for palladium-catalyzed carbon-carbon bond formation to create biaryl structures.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where fluorinated aromatic units are valuable.
• Ligand and Catalyst Preparation: Used as a precursor for synthesizing specialized ligands and catalysts in asymmetric synthesis and other catalytic processes.
• Chemical Biology & Diagnostics: Acts as a building block for probes and molecular tags used in biochemical assays and diagnostic tool development.

Basic Information

Product Name	3,4-Difluorophenylboronic Acid-1,3-Propanediol Ester
CAS No.	684648-49-5
Molecular Formula	C9H9BF2O3
Molecular Weight	213.98 g/mol
Synonyms	3,4-Difluorophenyl-1,3,2-dioxaborinane; (3,4-Difluorophenyl)-4,5-dihydro-1,3,2-dioxaborinane; 3,4-Difluorophenylboronic acid cyclic 1,3-propanediol ester; 5-(3,4-Difluorophenyl)-1,3,2-dioxaborinane; 3,4-Difluorophenylboronic acid pinacol ester analog (propanediol); Boronic acid, B-(3,4-difluorophenyl)-, cyclic 1,3-propanediol ester; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our 3,4-Difluorophenylboronic Acid-1,3-Propanediol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures the material's suitability for sensitive applications in pharmaceutical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and maintain purity. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.